Trapping bubbles, removing bubbles etc. in microfluidic devices is almost a science in itself (with many articles, patents etc.). The simplest way is de-gassing the liquid in advance, by pumping on it and exposing it to ultrasound. If you can accept the presence of the bubbles, having the liquid run around it, another primitive solution you could try is that sketched in "A unique solution for preventing clogging of flow channels by gas bubbles", Kohnle et al, IEEE?? 2002, p. 77 http://www.imtek.de/content/pdf/public/2002/solutionpreventingcloggingfl owbubbles.pdf Martin > -----Original Message----- > I work on the microfluidic devices. I found it really > annoying that when > I inject the flow there will be always some air bubbles > trapped in the > microfluidic devices (made of PDMS and glass). Is there any > way to get rid > of them?