The acetone won't "attack" the PDMS to make it dissolve or anything like that, but it will strongly affect it by making it swell. Up to you to determine how much of a problem that causes. I also found the reference mentioned below to be extremely helpful. -Joe Grogan Chris Bliss wrote: > Hi King, > The following is a great study investigating solvent compatibility with > PDMS: > J. N. Lee, C. Park, and G. M. Whitesides, "Solvent compatibility of > poly(dimethylsiloxane)-based microfluidic devices," Analytical Chemistry, > vol. 75, pp. 6544-6554, 2003.