Dear Satej, we've used a number of different silanes to make silicon dioxide surfaces hydrophobic. I would expect similar protocols to work for glass. Using the Yield Engineering Systems vacuum bake vapour prime oven, which in silicon processing this is used to deposit thin uniform layer of hmds to improve resist adhesion, we managed to get hydrophobic layers (as monitored by contact angle measurements). The silanes that we were using aminoproplytriethoxy silane and 4-aminobutyldimethylmethoxy silane (chosen as linker molecules to attach biological molecules), but there is no reason why you couldn't use different chemistries. The only aspect I cannot advise you on, is how long the chemically modified layer confers hydrophobicity. Hope this helps, Helen. Dr Helen Berney National Microelectronics Research Centre, Prospect Row, Cork, Ireland Tel +353-21-4904010 Fax 353-21-4270271 Email hberney@nmrc.ie Webpage http://www.nmrc.ie/research/transducers-group/index.html