I believe the following code creates a separate connection for each
Publisher and then reuses the connection
across requests (to any one publisher).

from ZEO import ClientStorage
from ZODB import DB
addr = ('localhost',9999)

from scgi.quixote_handler import QuixoteHandler, main
from quixote.publish import Publisher

class FacilitronPublisher(Publisher):
     def __init__(self,root_namespace,config=None):
         Publisher.__init__(self,root_namespace,config)
         storage = ClientStorage.ClientStorage(addr)
         self._db = DB(storage)
         self.conn=self._db.open()
         self.root=self.conn.root()

     def start_request(self,request):
         Publisher.start_request(self,request)
         #make sure updates by others are processed
         self.conn.sync()
         request.dbroot = self.root