I use Quixote, among other things, to generate server-side Excel worksheets and provide updatable reports to my users; on a windows platform through com, of course. Switching to Quixote 1.2 from some older release, this statement stopped working: import win32com.client The exception raised is: ImportError: No module named pythoncom I think the problem is similar to the Zope issue i read many times on the mailing list: importing the module before calling enable_ptl() fixes the thing. Because this simple workaround, i don't think the need for a bug fix is pressing: i'm reporting the issue for information purpose. Regards, Daniele